Do osteocytes contribute to phosphate homeostasis?

Osteocytes link bone maintenance to blood homeostasis.

O steocytes are the most abundant cell type in the bone, comprising more than 90% of all cells within the bone matrix or on bone surfaces. Osteocytes are derived from osteoblasts and are entombed in the bone matrix during bone deposition. Osteocytes were originally thought to be rather inert cells whose function was limited to maintaining bone matrix locally. However, osteocytes are connected t...

Regulation of Bone Homeostasis by Osteocytes.

New data concerning the function of osteocytes as the central regulators of bone homeostasis are briefly outlined. It is established that osteocytes are the main target cells for parathormone. They are a rich source of sclerostin, the main inhibitor of osteoblast activity, and of the RANKL cytokine, the most important regulator of osteoclastogenesis. Under shear stress causing microinjury, oste...

How international visitors do contribute to management processes of Perhentian Island Marine Park Malaysia?

Inorganic Phosphate Homeostasis

to transport Pi according to the dietary Pi: TRPt was always higher, for a given [Pt]P1, in the animals fed low than in those fed higher Pi diets. This diet-induced modification also occurred in the absence of thyroparathyroid glands, in the presence of the same calcemia and urinary pH, and during marked extracellular volume expansion. A time-course study in rats TPTX both before and during the...

Multiple Cellular Responses to Serotonin Contribute to Epithelial Homeostasis

Epithelial homeostasis incorporates the paradoxical concept of internal change (epithelial turnover) enabling the maintenance of anatomical status quo. Epithelial cell differentiation and cell loss (cell shedding and apoptosis) form important components of epithelial turnover. Although the mechanisms of cell loss are being uncovered the crucial triggers that modulate epithelial turnover through...